Sublingual Cialis – How does it work?

Erectile dysfunction is manifested in either inability to achieve erection, or to maintain it throughout the sexual intercourse. Cialis was developed after the legendary Viagra as its successor and a more powerful pill to help patients enjoy an uninhibited sex life during the period of 36 hours after the intake of the drug. Now think that most patients can take tadalafil, the main medicinal component of Cialis, every day. This lands you with a complete restoring of your sex life, practically.

Sublingual Cialis was developed recently to help achieve the effects of the drug within a much shorter time frame, but with the same longevity. Being produced in the form of a pastille, Sublingual Cialis dissolves in the mouth cavity and gets absorbed into the blood stream almost instantaneously, thus securing a momentary uptake and a speedy onset of the action.

Tadalafil, the active component of Sublingual Cialis, belongs to the class of drugs called phosphodiesterase type 5 inhibitors. Inhibitors of phosphodiesterase of type 5 have little effect on other types of phosphodiesterase, and tadalafil does not affect them at all. That is why Cialis and its generics do not have the side effect of visual impairment and colour perception.

Tadalafil is considered to be one of the safest drugs against erectile dysfunction, which contributes greatly to its growing popularity. To better understand the principles of tadalafil in the composition of Sublingual Cialis, let’s look closer at the mechanisms of erection itself.

Erection during sexual stimulation is caused by increased blood flow to the tissues of the penis due to relaxation of smooth muscles of arteries and the corpora cavernosa.

This process is mediated by the release of nitric oxide from the nerve endings and endothelial cells of the corpus cavernosum. Nitric oxide stimulates the synthesis of cGMP in smooth muscle cells. The accumulation of cGMP leads to muscle relaxation and increased blood flow to the cavernous bodies. The inhibition of PDE5 tadalafil accompanied by an increase of cGMP and enhanced erectile function. Since the initiation of the process for the local release of nitric oxide is required sexual stimulation, inhibition of PDE5 tadalafil in the absence of stimulation is not effective.

Studies in vitro have shown that tadalafil is a selective inhibitor of PDE5. PDE5 is found in corpus cavernosum smooth muscle, vascular smooth muscle and internal organs, skeletal muscle, platelets, kidney, lung cerebellum and pancreas.

Middle-aged men should take a dose of 20 mg for at least 16 minutes before anticipated sexual activity, regardless of the meal. Patients may attempt to carry out sexual intercourse at any time within 36 hours after admission in order to establish the optimal response time to Sublingual Cialis. The maximum frequency of intake is once during 24 hours.

Sublingual Cialis – How does it work?

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